AbstractID: 5219 Title: A response surface-based approach to beam orientation optimization in IMRT

ثبت نشده
چکیده

ID: 5219 Title: A response surface-based approach to beam orientation optimization in IMRT Purpose: To include all noncoplanar beam directions in the beam orientation optimization (BOO) problem in intensity-modulated radiation therapy (IMRT) treatment planning, and to demonstrate that high-quality treatment plans can be obtained using fewer beams than are typically used in equi-spaced plans. Method and Materials: Because the data storage requirements for each beam restrict the number of beams that can be considered in BOO, the majority of previous BOO research has focused on considering just coplanar angles and/or a handful of pre-selected noncoplanar directions, which comprise only a small subset of all solutions. In contrast, our approach allows for the generation of beam data for promising directions thus avoiding the data storage restriction and significantly increasing the size of the solution space, possibly leading to improved treatment plans. We use a response surface (RS) method that allows us to generate the beam data on-thefly only as necessary. We consider the problem of adding a single (noncoplanar) beam to a locally optimal 3-beam solution, thus yielding a 4-beam plan. Several varying implementations of the RS algorithm were tested on six head-and-neck cases using gantry and couch rotations, each on a 10° grid. Results: The 4-beam treatment plans obtained using the RS method were comparable to locally optimal 4-beam solutions, and were also comparable to the 5and 7-beam equi-spaced plans typically used in head-and-neck treatment plans. Conclusion: For head-and-neck cases, quality plans with fewer beams than standard 5-7 beam treatment plans can be obtained if BOO is applied. While the inclusion of noncoplanar orientations in BOO is useful in terms of improving the FMO objective function, the resulting improvements in the treatment plan are not always clinically significant. This work supported in part by NSF DMI-0457394 and the NSF Alliances for Graduation Education and the Professoriate and Graduate Research Fellowship programs.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Iterative Approach for Automatic Beam Angle Selection in Intensity Modulated Radiation Therapy Planning

Introduction: Beam-angle optimization (BAO) is a computationally intensive problem for a number of reasons. First, the search space of the solutions is huge, requiring enumeration of all possible beam orientation combinations. For example, when choosing 4 angles out of 36 candidate beam angles, C36 = 58905 possible combinations exist.  Second, any change in a   beam 4 config...

متن کامل

AbstractID: 8181 Title: An algorithm to incorporate leaf transmission and head scatter corrections into step-and-shoot leaf sequences for IMRT

ID: 8181 Title: An algorithm to incorporate leaf transmission and head scatter corrections into step-and-shoot leaf sequences for IMRT Leaf transmission and head scatter are two most important factors that influence IMRT delivery and should be fully taken into account when generating MLC leaf sequences. Significant discrepancies between the desired and delivered intensity profiles could otherwi...

متن کامل

A Response Surface Approach to Beam Orientation Optimization in Intensity-Modulated Radiation Therapy Treatment Planning

W view the beam orientation optimization (BOO) problem in intensity modulated radiation therapy (IMRT) treatment planning as a global optimization problem with expensive objective function evaluations. We propose a response surface method that, in contrast with other approaches, allows for the generation of problem data only for promising beam orientations as the algorithm progresses. This enab...

متن کامل

AbstractID: 1109 Title: Integral Dose in External Beam Photon Radiotherapy

ID: 1109 Title: Integral Dose in External Beam Photon Radiotherapy Integral dose is the volume integral of the dose deposited in the patient and is equal to the mean dose times the volume. The integral dose is also the area under the curve of a differential dose absolute-volume histogram. It is widely believed that IMRT increases the integral dose to normal tissues as compared to conventional r...

متن کامل

Intensity Modulated Arc Therapy: Technology and Clinical Implementation

ID: 10351 Title: Advances in arc therapy Intensity Modulated Arc Therapy: Technology and Clinical Implementation Cedric X. Yu University of Maryland School of Medicine AbstractID: 10351 Title: Advances in arc therapyID: 10351 Title: Advances in arc therapy Abstract Intensity modulated arc therapy (IMAT) was proposed by Yu as an alternative to Tomotherapy. Over more than a decade, many progresse...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2006